Maximal Rates of Excretion
نویسنده
چکیده
Received for publication 8 February 1973 and in revised form 18 April 1973. measured with 3H20. Then MIRUS is calculated as: ([mg urea N excreted between 8 and 24 h after dose E] + [BUN at 24 h-BUN at 8 h] X [body water]) X (100/% recovery ["C]urea) X (1/kg BW314) X (1/ 16h). MRUS in 10 normal subjects averaged 65 mg urea N/h per kg BW"' (range 55-76), and in 34 cirrhotics 27 mg urea N/h per kg BW3' (range 6-64). Among 19 cirrhotic patients fed 40, 60, 80, or 100 g protein daily for successive 10 day periods, the occurrences of hyperammonemia, hyperaminoacidemia, and encephalopathy at each level of protein intake were inversely related to MRUS value.
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